Panel Discussion: Demonstrating Degrader Efficacy
Time: 4:25 pm
day: Agenda: TPD: Emerging Disease Applications Beyond Oncology
• What is the challenge behind demonstrating degrader efficacy?
• What methods are currently followed to overcome the challenge of showing degrader targeting to the protein of interest?
• Establishing correlation between ubiquitination and target degradation, in vitro and in cell system remains a challenge. Tackling this problem will be key to establishing structure-activity relationship of PROTACs
• Impact of mechanisms involved in target protein’s stability and degradation at steady state on the PROTAC driven degradation.